口服生育三稀酚對頭髮生長影響的臨床實驗(下)

Effects of Tocotrienol Supplementation on Hair Growth in Human Volunteers
補充生育三稀酚對頭髮生長的影響


 


研究結果與討論

三十八位有異常掉髮情況或禿頭的志願受試者參加了研究，口服生育三稀酚組有21名志願者（19男2女），安慰劑組（對照組）有17個志願者（全部為男性）。該研究的人口年齡介於 18至59歲。受試者年齡範圍廣泛，因為掉髮是不受年齡之限制。年輕的成年人與老年人都會有受到掉髮問題的影響。此外，掉髮可能是由於營養缺乏和氧化壓力所導致，從而影響廣泛的年齡組。受試者掉髮問題大約有2~5年的時間。

研究開始前，針對受試組成員的頭髮數以及頭髮重量加以評估。安慰劑組受試者的毛髮的平均數目基線為289.0 ± 98.3，而補充生育三稀酚組為284.8 ± 111.3。至於20股頭髮平均重量，安慰劑組受試者的毛髮的平均數目基線為0.1002克和 ±0.0639，而補充生育三稀酚組為0.0920 ± 0.0565克。比較兩組的兩個參數並沒有顯著差異（P> 0.05）。

三十五位受試者完成了整個研究，並評價補充生育三稀酚的效果。三名受試者中止研究，一位(女)是生育三稀酚組，和兩位安慰劑組。每個月記錄與訪視過程中，補充生育三稀酚的順從性是令人滿意的。兩組皆無嚴重藥物反應或有關的記錄。從而表明，持續8個月服用100毫克的生育三稀酚是可以忍受的。研究方案也被認為是令人滿意的，沒有偏差協定的記錄。

表1顯示了受試者在基線，第4和第8個月的頭髮數量變化，以及髮量增加的百分比變化。顯而易見的是，生育三稀酚補充組，從基線到第8個月的時間，頭髮數量有逐漸增加，最後平均增幅超過 34％。相比之下，安慰劑組受試者沒有表現出任何明顯的髮量增加，約減少0.1％。杜克的事後檢驗表明(Tukey’s post-hoc test)，補充生育三稀酚的受試者頭髮增加並無安慰劑效應。成對比較還表明，8個月的時間，補充生育三稀酚組和安慰劑組噢試者的頭髮數量有顯著差異。

 

研究結束時，對於頭髮數量增加的效果評估，有一個志願受試者例外。整體而言，8名志願者（40.0％）顯示頭髮增加了50％以上，1名志願（5.0％）有25％至50％的增幅，9名受試者（45.0％）有增加10％至25％，而1名受試者（5.0％ ）為頭髮增加不到10％。只有1名受試者（5.0％）髮量有些微減少。另一方面，在8個月後，在安慰劑組有8個志願者顯示有增加頭髮的數量，1名（6.7％），顯示超過 20％的增長，其餘 7名（46.7％），顯示微不足道(negligible)的增加。7名受試者（46.7％）頭髮減少。

然而，兩組的頭髮重量並沒有顯著增加。生育三稀酚補充組，平均百分比增重了5.9％的，而安慰劑組有輕微下降2.0％（見表 2）。研究結果之後，另行補充相關的研究顯示，抗氧化劑可能被用來控制雄性禿掉髮。

 

結論

總之，本試驗表明，補充生育三稀酚膠囊的受試者與安慰劑組相比，頭髮數量有增加。一種可能的解釋，效果可能是由於強大的抗氧化活性的生育三烯酚，以幫助降低頭皮的脂質過氧化和氧化壓力。

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